Table 4. Nausea, Vomiting, Depression, Anxiety and Stress in the Third Trimester in Women Previously Hospitalised with Hyperemesis Gravidarum Compared to Controls.

	Hyperemesis Gravidarum n = 121	Controls n = 113	P value	Relative Risk 95% Confidence Interval	Adjusted P value	Adjusted Odds Ratio (95% Confidence Interval)
Nausea*	19 (15.7)	18 (15.9)	P = 0.99	RR 1.0 95% CI 0.5–2.0	P = 0.43	AOR 1.4 (0.6–3.0)
Vomiting†	12 (9.9)	16 (14.2)	P = 0.42	RR 0.7 95% CI 0.3–1.4	P = 0.49	AOR 0.7 (0.3–1.8)
Depression‡	5 (4.1)	16 (14.2)	P = 0.011	RR 0.3 95% CI 0.1–0.8	P = 0.003	AOR 0.1 (0.03–0.5)
Anxiety§	23 (19.0)	69 (61.1)	P<0.001	RR 0.3 95% CI 0.2–0.5	P<0.001	AOR 0.11 (0.05–0.23)
Stress∥	4 (3.3)	23 (20.4)	P<0.001	RR 0.2 95% CI 0.1–0.5	P<0.001	AOR 0.08 (0.02–0.33)

Data expressed as number (%). Analyses are by Fisher Exact test. All tests are 2-sided. Adjustment made for maternal age, ethnicity, educational attainment and hyperemesis gravidarum in a previous pregnancy as these characteristics are significantly different between the hyperemesis gravidarum and control groups

*At least one day of nausea in the last week

^†At least one day of vomiting in the last week

^‡A calculated score of at least 10 on the summated (then doubled) scores of the depression component of the 21-stem Depression, Anxiety and Stress Scales

^§A calculated score of at least 8 on the summated (then doubled) scores of the anxiety component of the 21-stem Depression, Anxiety and Stress Scales

^∥A calculated score of at least 15 on the summated (then doubled) scores of the stress component of the 21-stem Depression, Anxiety and Stress Scales