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. 2014 Mar 17;9(3):e92054. doi: 10.1371/journal.pone.0092054

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© 2014 Samuelson et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Representative dot plots showing Igλ1 versus B220 expression on total splenocytes from 6-month-old 3H9 Tg Blk^+/+ and 3H9 Tg Blk^+/− mice. Numbers in plots represent percentage of anti-DNA B cells (B220⁺ Igλ1⁺). (B) Graph comparing absolute numbers of anti-DNA B cells in the spleens of 6-month-old 3H9 Tg Blk^+/+ (n = 7) and 3H9 Tg Blk^+/− (n = 8) mice. (C) Histograms comparing IgM^a (allotype of 3H9 IgH transgene) and IgM^b (allotype of endogenous IgH) surface levels on gated Igλ1⁺ B cells from 6-month-old 3H9 Tg Blk^+/+ (n = 7) and 3H9 Tg Blk^+/− (n = 8) mice. (D) Histograms comparing CD93, CD23, CD21 and CD22 levels on gated Igκ⁺ (contains B cells that do not bind DNA) and Igλ1⁺ B cells from 6-month-old 3H9 Tg Blk^+/+ (n = 7) and 3H9 Tg Blk^+/− (n = 8) mice. (E) Comparison of anti-dsDNA IgG antibodies in 6-month-old 3H9 Tg Blk^+/+ and 3H9 Tg Blk^+/− mice. Each symbol represents an individual mouse.