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. 2014 Mar 17;9(3):e92054. doi: 10.1371/journal.pone.0092054

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© 2014 Samuelson et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Representative histograms showing ICOSL levels on follicular (FO), marginal zone (MZ) and splenic B1 (B1s) B cells from 3-month-old B6 (n = 6), Blk^+/− (n = 6), B6.lpr (n = 7) and Blk^+/−.lpr (n = 8) mice. (B) Histogram comparing B cell size, using FSC units, among 3-month-old B6 (n = 6), Blk^+/− (n = 6), B6.lpr (n = 7) and Blk^+/−.lpr (n = 8) mice. (C) Comparison of the BAFF serum levels in 3-month-old B6, Blk^+/−, B6.lpr and Blk^+/−.lpr mice. Each symbol represents an individual mouse. (D) Representative histograms comparing BAFF-R levels on total (CD19⁺) (top) and FO B cells (bottom) from 3-month-old B6 (n = 8), Blk^+/− (n = 10), B6.lpr (n = 13) and Blk^+/−.lpr (n = 12) mice. (E) Representative histograms showing the expression of ICOS on CD4⁺, CD8⁺, DN αβ, and γδ T cells subsets from the spleens of 3-month-old B6.lpr and Blk^+/−.lpr mice. ICOS levels on the corresponding T cell subsets from age-matched B6 mice are also shown (shaded histogram). Adjacent graph compares ICOS levels (MFI) on each T cell subset between 3-month-old B6 (n = 6) and Blk^+/− (n = 6) mice and between 3-month-old B6.lpr (n = 7) and Blk^+/−.lpr (n = 8) mice.