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Effects of nicousamide and losartan on (A) average systolic pressure (SAP), (B) average diastolic pressure (DAP) and (C) heart rate (HR) in SHRs after a 17-week treatment are shown. Nicousamide markedly decreased SAP and DAP at doses of 30 and 45 mg/kg, although its effect was weaker compared to losartan (10 mg/kg). *P<0.05; **P<0.01 when compared to untreated control SHRs group. SHRs, spontaneously hypertensive rats.
