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. 2014 Mar 17;9(3):e92172. doi: 10.1371/journal.pone.0092172

Figure 4. Higher p-ERK1/2 correlated with 5-FU resistance and BIKDDA could enhance the cytotoxicity of 5-FU.

Figure 4

A. Kaplan-Meier curve of disease-free survival showed the decreased disease-free survival time of high p-ERK1/2 group who received adjuvant 5-FU based chemotherapy than the low. B and C. High levels of p-ERK1/2 correlated with 5-FU resistance (patients with metastasis and/or recurrence after adjuvant 5-FU based chemotherapy). After stratified by lymph node metastasis the correlation also exhibited statistics significance in metastasis positive cohort. D. 435 and 231 cells were transfected with vector control or BikDDA in combination with 25 ug/ml 5-FU or not, 24h later cell viability was analyzed by MTT assay (vector transfected only setting as 100%). These data showed BIKDDA can enhance the cytotoxicity of 5-FU.