Skip to main content
. 2014 Mar 17;9(3):e92227. doi: 10.1371/journal.pone.0092227

Figure 3. Effect of the CXCR4 antagonist, AMD3100 on glomerulosclerosis and renal fibrosis in subtotally nephrectomized (SNx) rats.

Figure 3

PAS-stained kidney sections from sham (A and B) and SNx (C and D) rats treated with vehicle (A and C) or AMD3100 (B and D) for eight weeks. Original magnification x400. (E) Glomerulosclerosis index. Tubulointerstitial collagen IV immunostaining of kidney sections from sham (F and G) and SNx (H and I) rats treated with vehicle (F and H) or AMD3100 (G and I) for eight weeks. Original magnification x160. (J) Quantitation of tubulointerstitial collagen IV. AU = arbitrary units. *p<0.001 vs. sham, †p<0.05 vs. SNx + vehicle, ‡p<0.05 vs. sham, §p<0.01 vs. SNx + vehicle.