Table 1. Functional characteristics of sham and subtotal nephrectomy (SNx) rats treated with vehicle or AMD3100.
Body weight (g) | Left kidney weight (g) | Left kidney weight / body weight (%) | SBP (mmHg) | GFR (ml/min/kg) | Urine protein excretion (mg/day) | |
Sham + vehicle | 186±3 | 0.56±0.01 | 0.300±0.005 | 113±2 | 5.36±0.25 | 1.71×/÷1.12 |
Sham + AMD3100 | 185±5 | 0.54±0.02 | 0.296±0.005 | 112±3 | 5.29±0.28 | 2.37×/÷1.08 |
SNx + vehicle | 172±3* † | 0.67±0.04‡§ | 0.400±0.031§¶ | 145±7‡§ | 3.22±0.32‡§ | 20.42×/÷1.52‡§ |
SNx + AMD3100 | 180±3 | 0.67±0.03‡§ | 0.378±0.016†‡ | 165±5‡§|| | 1.73±0.10‡§** | 50.70×/÷1.26‡§|| |
SBP = systolic blood pressure.
*p<0.05 vs. sham + vehicle, †p<0.05 vs. sham + AMD3100, ‡p<0.01 vs. sham + vehicle, §p<0.01 vs. sham + AMD3100, ¶p<0.001 vs. sham + vehicle, ||p<0.05 vs. SNx + vehicle, **p<0.01 vs. SNx + vehicle.