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. 2014 Mar 17;9(3):e92242. doi: 10.1371/journal.pone.0092242

Figure 5. Fasudil reduces the I/R-induced inflammatory status in hearts partially through its action on leukocytes.

Figure 5

I/R significantly induced expression levels of IL-6 mRNA (A), CCL2 mRNA (B), TNF-α mRNA (C), and IL-10 (D) in the heart. Data represent means from at least 4 mice each. * p<0.05, ** p<0.01. Fasudil and neutrophil depletion influence the expression of various cytokines 24 h after I/R in the heart. Expression levels of IL-6 mRNA (E), CCL2 mRNA (F), TNF-α mRNA (G), and IL-10 (H) in the heart. Data represent means from at least 5 mice each. * p<0.05, ** p<0.01.