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Expression pattern of three cartilage-specific genes. A) Sox 9: This transcription factor upregulated at day 14 of the cultures treated by 0.01 and 0.05 µM BIO (*indicates a P=0.01). In the control group, upregulation of this molecule occurred at day 21, indicating the delayed differentiation of the cells in this group compared to that in 0.01 and 0.05 µM BIO-treated cultures. This pattern of expression occurred regarding both B) aggrecan and C) collagen II expression.
