Table 1.

Ranges of antibiotic concentrations tested for determination of MICs (broth microdilution method) and MIECs (dye uptake assay) for 11 antibiotics against Francisella tularensis subsp. holarctica.

Antibiotics	Antibiotic targets	MIC (μg/mL)	MIEC (μg/mL)
Gentamicin	Ribosome	0.032–16	0.064–32
Ciprofloxacin	Type II topoisomerases	0.001–0.5	0.004–2.0
Levofloxacin	Type II topoisomerases	0.001–0.5	0.004–2.0
Moxifloxacin	Type II topoisomerases	0.001–0.5	0.004–2.0
Doxycycline	Ribosome	0.032–16	0.032–16
Erythromycin	Ribosome	0.25–128	0.25–128
Imipenem	Cell wall	0.25–128	0.25–128
Meropenem	Cell wall	0.25–128	0.25–128
Linezolid	Ribosome	0.064–32	0.064–32
Rifampicin	RNA polymerase	0.004–2.0	0.016–8.0
Daptomycin	Cytoplasmic membrane	0.5–256	0.5–256

MIC, minimum inhibitory concentration; MIEC, minimum inhibitory extracellular concentration.