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. Author manuscript; available in PMC: 2014 Dec 26.
Published in final edited form as: Neuroscience. 2013 Oct 10;255:219–225. doi: 10.1016/j.neuroscience.2013.09.062

Figure 1. Hormone therapy treatment groups.

Figure 1

All hormone therapy was delivered using a calendar of ten 28-day treatment periods, each representing one menstrual “cycle.” The Continuous E group received a single, steady dose of estradiol through subcutaneously implanted Silastic capsules for the duration of the study. The Continuous E + Cyclic P group received the same continuous estradiol treatment, with the addition of an oral dose of progesterone taken daily on days 10-19 of each 28-day treatment cycle. The Cyclic E group received an injection of estradiol intramuscularly on the first day of each 28-day treatment cycle. The Vehicle group received an injection of oil vehicle on the first day of each 28-day treatment cycle. All animals were perfused on day 20 of the tenth treatment cycle.