Figure 2.

Brain networks whose engagement correlated with individual variation in the attentional bias effect for cocaine use cues. Three of the ICA-derived brain networks (IC 6, IC 12, and IC 19) demonstrated task-related activity that significantly correlated with variation in the attentional bias effect for cocaine use cues among cocaine-dependent men and women. Left: statistical maps depict the neural regions comprising each spatially independent network of activated brain areas. Right: regression plots demonstrate significant (all p<0.05) linear regressions between activity in each network and attentional bias for cocaine stimuli relative to neutral stimuli. A negative relationship (indicating less attentional bias with greater brain activity) was observed for IC 6, and positive relationships were observed for ICs 12 and 19. These relationships were strengthened when controlling for the variables of age, gender, cocaine use in the past 7 days, and impulsiveness.