Table 3. rs1344706 Risk Allele Dose Effect on Brain Activation During Mentalizing.

Region		MNI coordinates x, y, z (mm)			k	T	Z
Replication sample (N=188)
Middle temporal gyrus (TPJ)	L	−57	−64	21	73	4.56	4.56a
Superior frontal gyrus	L	−15	38	54	116	4.24	4.13
Supplementary motor area	L	−12	5	66		3.29	3.24
Middle temporal gyrus	L	−57	−10	−24	22	3.99	3.90
Medial frontal gyrus	L	−21	47	3	22	3.76	3.69
Medial frontal gyrus	R	12	47	27	18	3.74	b3.67
Anterior Cingulate Cortex	L/R	0	35	3	39	3.55	3.48
Cerebellum (Declive)	R	18	−76	−21	24	3.48	3.42
Posterior Cingulate Cortex	L	−3	−49	33	15	3.37	b3.32
Joint sample (N=297)
Middle temporal gyrus (TPJ)	L	−57	−61	18	29	5.28	5.16
Medial frontal gyrus	R	12	38	27	25	5.06	4.95
Inferior temporal gyrus	L	−57	−10	−27	3	4.82	4.73
Medial frontal gyrus	L	−6	38	39	9	4.74	4.65
Inferior parietal lobule	L	−51	−43	45	8	4.72	4.63
Posterior cingulate cortex	L	−6	−46	33	3	4.65	4.56
Supramarginal gyrus	L	−63	−40	36	4	4.58	4.50

Abbreviations: k, cluster size; L, left; MNI, coordinates Montreal Neurological Institute (MNI) space coordinates; N, sample size; R, right; TPJ, temporo-parietal junction; x, y, z=location in mm with the three axes.

Brain regions showing a significant negative rs1344706 risk allele dose effect for the Theory of Mind>control contrast. Replication sample: Reported results are p<0.001 uncorrected. Joint sample: Reported results are p<0.05 FWE for the whole brain.

^aRegion significant at p<0.05 FWE (family-wise error correction) across the whole brain.

^bRegion significant at p<0.05 FWE for respective region of interest.