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. 2014 Feb 20;9(1):39–48. doi: 10.17795/jjnpp-12530

Table 1. Chlorpheniramine Maleate Microparticle Formulations Prepared by the Ionotropic Gelation Method With Different Sodium Alginate:Chitosan Ratios, Without Chitosan and Ion (Ca2+) a.

Formulations Na-Alg:CS Ratio Cross-linked Insoluble Complexes
Aqueous Phase Ionotropic Gelation Agents
CM, g Water, mL Na-Alg, g Chitosan, g Acetic Solution (%0.5 v/v), mL Calcium Chloride, g
F1 1:0.27 0.25 100 1.2 0.325 100 1.3
F2 1:0.54 0.25 100 1.2 0.650 100 1.3
F3 1:1.1 0.25 100 1.2 1.3 100 1.3
F4 0.25 100 1.2 100 0.65
F5 0.25 100 1.2 100 1.3
F6 0.25 100 1.2 100 2.6

a Abbreviations: Na-Alg, sodium alginate; CS: chitosan; CM, chlorpheniramine.