Table 1. Chlorpheniramine Maleate Microparticle Formulations Prepared by the Ionotropic Gelation Method With Different Sodium Alginate:Chitosan Ratios, Without Chitosan and Ion (Ca2+) a.
| Formulations | Na-Alg:CS Ratio | Cross-linked Insoluble Complexes | |||||
|---|---|---|---|---|---|---|---|
| Aqueous Phase | Ionotropic Gelation Agents | ||||||
| CM, g | Water, mL | Na-Alg, g | Chitosan, g | Acetic Solution (%0.5 v/v), mL | Calcium Chloride, g | ||
| F1 | 1:0.27 | 0.25 | 100 | 1.2 | 0.325 | 100 | 1.3 |
| F2 | 1:0.54 | 0.25 | 100 | 1.2 | 0.650 | 100 | 1.3 |
| F3 | 1:1.1 | 0.25 | 100 | 1.2 | 1.3 | 100 | 1.3 |
| F4 | 0.25 | 100 | 1.2 | 100 | 0.65 | ||
| F5 | 0.25 | 100 | 1.2 | 100 | 1.3 | ||
| F6 | 0.25 | 100 | 1.2 | 100 | 2.6 | ||
a Abbreviations: Na-Alg, sodium alginate; CS: chitosan; CM, chlorpheniramine.