Table V.

Pharmacokinetic parameters and 90% CIs* for the ratios of the geometric means of their log-transformed values for the 2 azithromycin capsule formulations (n = 12, where n is the number of volunteers).

Pharmacokinetic Parameters	Test Formulation	Reference Formulation	P	T/R Point Estimate
Cmax (µg/mL)
Mean (SD)	0.34 (0.03)	0.38 (0.04)	0.06	0.88
Range	0.31–0.40	0.31–0.47		0.83–0.93*
Median	0.34	0.39
%CV	8.99	14.21
Tmax (h)
Mean (SD)	2.83 (0.39)	2.91 (0.29)	0.56	0.97
Range	2.00–3.00	2.00–3.00		0.86–1.08*
Median	3.00	3.00
%CV	13.74	9.90
AUC0–48 (h·µg/mL)
Mean (SD)	2.75 (0.46)	2.85 (0.48)	0.61	0.96
Range	2.00–3.76	2.14–3.55		0.85–1.10*
Median	2.72	2.87
%CV	16.74	16.26
t1/2 (h)
Mean (SD)	9.20 (1.63)	8.79 (1.02)	0.47	1.05
Range	5.96–12.03	6.83–10.70		0.92–1.17*
Median	8.70	8.81
MRT (h)
Mean (SD)	13.27 (2.35)	12.68 (1.48)	0.47	1.05
Range	8.60–17.35	9.85–15.5		0.92–1.16*
Median	12.55	12.70
AUMC (h·µg/mL)
Mean (SD)	36.90 (11.02)	36.57 (9.14)	0.94	–
Range	23.98–61.34	21.08–50.82		–
Median	33.31	36.76

AUMC = area under moment curve; CV = coefficient of variation; MRT = mean residence time; T/R = test/reference.