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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Curr Drug Targets. 2013 Apr;14(4):441–449. doi: 10.2174/1389450111314040005

Figure 1. Androgen Receptor Functional Domains.

Figure 1

The AR possesses a modular domain organization common to members of the steroid hormone receptor family of nuclear receptor transcription factors. The amino-terminal domain (NTD) harbors transcriptional activation unit (TAU)-1 and TAU-5. Transcriptional activation function (AF)-1a and AF-1b are subdomains of TAU-1. The DNA binding domain (DBD) is comprised of two zinc finger motifs (Zn), and a flexible hinge (H) region containing the AR nuclear localization signal (NLS). The COOH-terminal domain (CTD) harbors the ligand binding domain (LBD), a ligand-regulated nuclear export signal (NES), and the protein interaction domains AF-2 and binding function (BF)-3.