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. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: J Immunol. 2014 Feb 10;192(6):2576–2584. doi: 10.4049/jimmunol.1301857

Figure 6. Anti-DC-HIL treatment abrogated T cell-suppressive activity of MDSC.

Figure 6

Each myeloid cell subset was purified from EAE-disease mice and cocultured with CFSE-labeled WTT cells activated by anti-CD3/CD28 Ab in the presence of anti-DC-HIL mAb or control Ab (IgG) at 25 or 50 μg/ml. Dilution of CFSE fluorescent intensity was measured by flow cytometry (A) or IL-2 production assayed (B) (mean ± sd, n=3). “T cells alone” mean T cell culture with anti-CD3/CD28 cells but without myeloid cells. *p<0.001 between DC and MDSC. Data are representative of 3 independent experiments.