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. Author manuscript; available in PMC: 2014 Jun 19.
Published in final edited form as: Nature. 2013 Dec 1;504(7480):460–464. doi: 10.1038/nature12805

Extended Data Figure 7. Hypermethylation in Tet1-KO sperm at imprinted genes.

Extended Data Figure 7

a,b, Mouse phenotype ontology enrichment of hypermethylated sites in Tet1-KO sperm (a) and hypermethylated sites in both Tet1-KO E13.5 PGCs and sperm (b). c, Representative DNA methylation profiles of selected imprinting genes in sperm analyzed by RRBS. Vertical grey lines represent the sequence read depth for each cytosine scored, and 30 reads were shown at most. The vertical red lines represent percentage of methylation for each cytosine scored, which range from 0 to 50%. For each gene, RefSeq exon organization (blue) and location of CGIs (green) are shown at the bottom.