Table 5.
Comparison between OXC treatment once daily and twice daily over time (n=13)
| Once daily (n=4)
|
Twice daily (n=9)
|
p-value | |||
|---|---|---|---|---|---|
| Baseline | 6 mon | Baseline | 6 mon | ||
| Seizure frequency | 0.4±0.4 | 0.4±0.6 | 1.0±0.8 | 0.8±0.7 | NS |
| Seizure freedom | 2 (50%) | 5 (56%) | NS | ||
| Reduction > 50% | 1 (25%) | 1 (11%)* | p>0.05 | ||
| Spike index | |||||
| Left | 27.6±26.5 | 33.0±19.2 | 12.8±15.8 | 22.8±18.1* | p>0.05 |
| Right | 21.0±27.1 | 24.7±24.0 | 13.0±13.0 | 16.3±16.8 | NS |
| EEG (-)† | 0 (0%) | 1 (11%) | NS | ||
| FIQ | 94.8±10.8 | 98.0±10.0 | 95.8±11.0 | 97.4±9.1 | NS |
| VIQ | 105.3±12.5 | 92.0±7.1 | 98.1±10.4 | 91.8±10.1 | NS |
| PIQ | 92.5±14.7 | 104.5±9.2 | 96.8±10.6 | 103.6±6.1 | NS |
| Aggression‡ | 38.0±11.5 | 31.0±11.3 | 46.4±11.6 | 50.8±15.58* | p>0.05 |
p values based on two way repeated measures, ANOVA.
FIQ, Full-scale intelligence quotient; VIQ, Verbal intelligence quotient; PIQ, Performance intelligence quotient; NS, Not significant statistically.
*
p<0.05.
†
EEG (-), normalization of sleep EEG.
‡
Aggression, aggression on K-CBCL.