Table 1.

Androgen-sensitive and androgen-insensitive cellular processes

Group	Cellular process	ICAT-labeled protein ratios ≥1.6	ICAT-labeled proteins in cellular process	Observed compared with expected	p-value
38	RNA splicing	12	14	Over	5.92E-05
18	Energy generation	38	74	Over	3.01E-04
25	Nucleotide metabolism	30	56	Over	5.20E-04
43	Vesicular transport	12	68	Under	1.87E-03
19	Lipid, fat and sterol metabolism	31	63	Over	2.30E-03
37	RNA processing/modification	25	48	Over	2.32E-03
35	Protein synthesis	17	84	Under	3.11E-03

For each cellular process category, the observed number of proteins showing an ICAT ratio ≥1.6 was compared to the number expected at random. Using the hypergeometric distribution, a p-value was calculated for each cellular process category from four numbers: the total number of ICAT-reagent labeled proteins (1,064), the total number of proteins with ICAT ratios ≥1.6 (350), the number of ICAT-reagent labeled proteins in the cellular process category, and the number of ICAT-reagent labeled proteins in the cellular process category with a ratio ≥1.6. Cellular process categories showing low p-values are shown. Each of these has either an over-representation of changed proteins or an under-representation.