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. 2014 Apr 1;141(7):1442–1452. doi: 10.1242/dev.103283

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© 2014. Published by The Company of Biologists Ltd

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Fig. 7. — Analysis of cap mesenchyme and UB branching in the Osr1^c/-;Six2^GCE/+ mutant embryos. (A-F) Immunofluorescence detection of Six2 (green) and pan-cytokeratin (red) in developing kidneys of Osr1^c/+;Six2^GCE/+ (A,C,E) and Osr1^c/-;Six2^GCE/+ (B,D,F) embryos at E11.5 (A,B), E12.5 (C,D) and E13.5 (E,F). Arrows in D indicate abnormal mesenchymal aggregates surrounding the UB in the E12.5 Osr1^c/-;Six2^GCE/+ mutant kidney. Arrowheads in F indicate large epithelializing aggregates in place of the CM surrounding the UBs. Scale bars: 100 μm. (G-J) Whole-mount immunofluorescence detection of Cited1 (green, G,H) or Jag1 (green, I,J) and pan-cytokeratin (red) in cultured Osr1^c/+;Six2^GCE/+ (G,I) and Osr1^c/-;Six2^GCE/+ (H,J) kidney explants. Scale bars: 200 μm.