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. 2014 Apr 1;141(7):1442–1452. doi: 10.1242/dev.103283

Fig. 9.

Fig. 9.

Osr1 interacts with both TCF and Groucho/Tle proteins and stabilizes the repressor complex. (A) Osr1 forms complexes with Tle2 and Tle3, but not with Aes. (B) Six2 was not co-immunoprecipitated with Tle2 or Tle3. (C) When co-expressed with Osr1 and Six2, Tle2 and Tle3 were detected in complexes with Osr1 but not Six2. (D) Osr1 formed complexes with Tcf4b. (E,F) Addition of Osr1 significantly increased the amount of Tle2/3 proteins co-immunoprecipitated with Tcf4b. Error bars indicate s.e.m. *P<0.05. (G,H) Six2 interacts with Tcf4b but does not enhance Tcf4b interaction with Tle2/3. NS, not significantly different.