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Attenuation of the Fzy-dependent survival mechanism links catastrophic cellular stress to the activation of necrosis in neuroblasts. (A) Fzy maintains neuroblast survival by targeting an unidentified necrosis activator for degradation through an APC/C-dependent mechanism. Wild-type Fzy (blue) recruits the presumed necrosis activator for degradation (purple). The Fzy5032 mutant protein is unable to recruit the necrosis activator to APC/C, leading to the necrosis of neuroblasts.
