TABLE 3.
Chromosomal Aberrations of IPMNs in Comparison to PDAC
| Chromosomal Aberration |
% IPMNs With High Grade Dysplasia or Invasion (n = 8) |
% in PDAC* | P Values† |
|---|---|---|---|
| Loss of 2 | 50.0 | 24.3 | 0.202 |
| Loss of 4q | 62.5 | 32.2 | 0.121 |
| Loss of 5q | 62.5 | 18.9 | 0.0224 |
| Loss of 6q | 75.0 | 33.6 | 0.0264 |
| Gain of 7 | 50.0 | 43.3 | 0.727 |
| Loss of 8p | 50.0 | 42.2 | 0.721 |
| Loss of 10q | 62.5 | 25.0 | 0.0878 |
| Loss of 11q | 50.0 | 5.5 | 0.00039 |
| Loss of 13q | 50.0 | 27.0 | 0.224 |
| Loss of 15q | 50.0 | 40.0 | 0.704 |
| Loss of 18q | 62.5 | 67.8 | 0.714 |
| Gain of 19q | 50.0 | 23.3 | 0.197 |
| Loss of 22q | 37.5 | 35.6 | 1.000 |
Prevalence of chromosomal aberrations in PDAC were calculated by compiling the data of 5 representative publications (Aguirre AJ,31 Schleger C,32 Mahlamaki EH,43 Solinas-Toldo S,33 and Bardi G),44 with the percentages calculated by dividing the total number of described aberrations by the total number of samples included into these 5 publications. P-values were calculated with a 2-tailed Fisher exact test.
*
Previously published data.
†
Fisher exact test; 2-tailed.