Fig. 2.

The conductance domain of the M2 proton channel from Influenza A shown in a lipid bilayer of dioleoylphosphatidylcholine and dioleoylphoshatidylethanolamine in which the structural data were obtained and in which the structure was refined using restrained molecular dynamics (PDB: 2L0J) [80]. The protein structure shown in yellow with a helical cartoon and sticks for the heavy atoms is a tetrameric structure composed of a TM and an amphipathic helix, the latter interacting with both the hydrophobic and hydrophilic regions of the bilayer. The heavy atoms of the lipids are shown as space filling spheres. Carbon is green or yellow, oxygen is red, phosphorous is orange, and nitrogen is blue.