Table 3.
Laboratory, diastolic function, systolic function and hemodynamic changes with transfusion in male, female and pooled groups.
| Laboratory Value | Male | Female | Combined |
|---|---|---|---|
| Pre to Post Change | Pre to Post Change | Pre to Post Change | |
| White Blood Cell Count (K/uL) | 0.1 ±0.7 | −1.6 ±0.9 | −0.8 ±0.6 |
| Hemoglobin (g/dL) | 2.3 ±0.2 | 2.2 ±0.3 | 2.3 ±0.2 |
| Hematocrit (%) | 6.3 ±0.7 | 5.3 ±1.0 | 5.8 ±0.6 |
| Platelet Count (K/uL) | −11.8 ±15.0 | −27.5 ±15.2 | −20.0 ±10.6 |
| Hemoglobin S (%) | −6 ±2.7 | −4.8 ±1.1 | −5.4 ±1.4 |
| Reticulocyte Count (%) | −4.4 ±0.8 | −3.8 ±1.2 | −4.0 ±0.7 |
| LDH (U/L) | −68.3 ±62.9 | −31.9 ±41.6 | −49.3 ±36.4 |
| hsCRP (mg/L) | −4.4 ±2.1 | 0.4 ±2.3 | −1.9 ±1.6 |
| Arginine:Ornithine | −0.1 ±0.1 | 0.2 ±0.2 | 0.0 ±0.1 |
| Plasma Free Hemoglobin (mg/dL) | −4.2 ±5.8 | 1.8 ±5.8 | −1.5 ±4.1 |
| Measures of Diastolic Function | |||
| Mitral Valve E/A | 0.2 ±0.1 | 0.2 ±0.1 | 0.2 ±0.1 |
| Lateral Mitral E/e′ | 0.2 ±0.5 | −0.1 ±0.5 | 0.04 ±0.33 |
| Medial Mitral E/e′ | 0.3 ±0.3 | 0.0 ±0.5 | 0.2 ±0.3 |
| Tricuspid Valve E/A | 0.2 ±0.1 | 0.0 ±0.1 | 0.1 ±0.1 |
| Tricuspid Valve E/e′ | 0.3 ±0.4 | −0.4 ±0.5 | 0.04 ±0.34 |
| Measures of Systolic Function | |||
| LV SF (%) | −1.6 ±1.2 | −2.0 ±2.1 | −1.8 ±1.2 |
| LV EF (%) | −1.2 ±2.0 | −3.1 ±1.6 | −2.2 ±1.2 |
| Lateral Mitral Tei Index | −0.016 ±0.052 | 0.079 ±0.064 | 0.033 ±0.042 |
| Medial Mitral Tei Index | 0.004 ±0.036 | 0.007 ±0.034 | 0.006 ±0.024 |
| Tricuspid Valve Tei Index | 0.066 ±0.057 | 0.028 ±0.049 | 0.046 ±0.037 |
| Hemodynamics | |||
| Heart Rate (bpm) | −8.8 ±2.6 | −8.6 ±1.3 | −8.7 ±1.4 |
| Stroke Volume (ml) | −10.8 ±4.9 | 3.2 ±3.6** | −3.6 ±3.3 |
| Cardiac Index(L/min/m2) | −0.8 ±0.3 | −0.2 ±0.2* | −0.5 ±0.2 |
| Systolic Blood Pressure (mmHg) | −0.3 ±3.2 | −2.8 ±3.3 | −1.6 ±2.3 |
| Diastolic Blood Pressure (mmHg) | 3.8 ±3.4 | 3.2 ±2.6 | 3.5 ±2.1 |
| Mean Arterial Pressure (mmHg) | 2.5 ±2.9 | 1.6 ±2.4 | 2.0 ±1.8 |
| TR Jet (cm/s) | −6.8 ±8.4 | −3.0 ±6.3 | −4.8 ±5.1 |
| SVRI (mmHg/(L/min/m2) | 9.2 ±2.5 | 2.5 ±1.8** | 5.7 ±1.6 |
| PVRI (mmHg/(L/min/m2)) | 1.2 ±0.5 | 0.2 ±0.4 | 0.6 ±0.3 |
| Oxygen Delivery (ml/L/min/m2) | −26.7 ±34.7 | 70.8 ±30.6** | 24.0 ±24.6 |
| NIRS (%) | −5.4 ±4.2 | 4.1 ±1.8* | −0.6 ±2.5 |
Significant pre to post transfusion changes (p < 0.05) are indicated by bold type while trends (0.05 < p < 0.10) are italicized.
*
indicates a trend difference between male and female patients (0.05 < p < 0.10),
**
indicates a significant difference (p < 0.05).
LDH = lactate dehydrogenase, hsCRP = high sensitivity C-reactive protein, LV EF = left ventricle ejection fraction, LV SF = left ventricle shortening fraction, TR jet = tricuspid regurgitation jet, SVRI = systemic vascular resistance index, PVRI = pulmonary vascular resistance index, NIRS = near infrared spectroscopy