Table 1. Baseline comparison between subjects exposed to ACEI/ARB and the control group.
| Covariate | ACEI/ARB users (N=72) | Control group (N=705) | P -value |
|---|---|---|---|
| Male | 30 (42.0%) | 230 (33.0%) | 0.1214 |
| Smoking | |||
| Never | 29 (40.0%) | 360 (51.0%) | |
| Former | 34 (47.0%) | 262 (37.0%) | 0.1937 |
| Current | 9 (13.0%) | 83 (12.0%) | |
| Race | |||
| White | 56 (78.0%) | 626 (88.8%) | |
| Black | 15 (21.0%) | 78 (11.1%) | 0.0065 |
| Other | 1 (1.0%) | 1 (0.1%) | |
| Triglycerides (mg/dl) | 160.2 (±61.5) | 165.4 (±63.9) | 0.5109 |
| HDL (mg/dl) | 47.6 (±11.5) | 49 (±12.6) | 0.3785 |
| LDL (mg/dl) | 130.0 (±34.9) | 136.2 (±35.0) | 0.1502 |
| Age (years) | 71.8 (±4.4) | 72.5 (±5.0) | 0.2968 |
| BMI (kg/m2)a | 28.7 (±3.8) | 28.6 (±3.9) | 0.9278 |
| Number of antihypertensives | 1.9 (±0.9) | 1.7 (±0.8) | 0.2074 |
| Systolic blood pressure (mmHg) | 143.8 (±21.4) | 140.0 (±20.1) | 0.2120 |
| Fasting glucose (mg/dl) | 105.3 (±7.5) | 104.4 (±8.9) | 0.3737 |
| Frequencies of antihypertensive use at baseline | |||
| Beta blockers | 4 (5.6%) | 132 (18.7%) | 0.0051 |
| Thiazides | 7 (9.7%) | 118 (16.7%) | 0.1228 |
| Loop diuretics | 8 (11.1%) | 31 (4.4%) | 0.0129 |
| K sparing diuretic | 0 (0.0%) | 10 (1.4%) | 0.3091 |
| Calcium channel blocker | 13 (18.1%) | 61 (8.7%) | 0.0096 |
| Vasodilators | 10 (13.9%) | 66 (9.4%) | 0.2180 |
| Alpha blockers | 0 (0.0%) | 28 (4.0%) | 0.0850 |
| Angiotensin receptor blocker | 0 (0.0%) | 0 (0.0%) | |
Data are given as mean (SD) for continuous variables and as numbers (percent %) for categorical variables
a
BMI calculated as weight in kilograms divided by the square of height in meters