Table 1.
Main characteristics of included studies assessing the effectiveness of gentamicin impregnated collagen sponge in reducing post-operative sternal wound infection
| Reference | Patient group | Number of participants | Number of centres | Gentamicin sponge dose | Patient blinded? | Assessor blinded? | Definition of SWI | Follow-up duration |
|---|---|---|---|---|---|---|---|---|
| Eklund et al6 | Elective CABG | 542 | 1 (Finland) | 130mg gentamicin (1 sponge) | No | Yes | CDC 1992 | 3 months |
| Friberg et al7 | Cardiac surgery through median sternotomy | 1,950 | 2 (Sweden) | 260mg gentamicin (2 sponges) | Yes | Yes | CDC 1992 (minor modifications) | 2 months |
| High risk subgroup: DM and/or BMI>25kg/m2 | 1,385 | |||||||
| Bennett-Guerrero et al8 | Elective CABG +/- AVR and high risk: DM and/ or BMI >30kg/m2 | 1,502 | 48 (US) | 260mg gentamicin (2 sponges) | Yes | Yes (consensus of 3 blinded assessors) | CDC 1992 + asepsis | 90 days |
SWI = sternal wound infection; CABG = coronary artery bypass graft; CDC = Centers for Disease Control; DM = diabetes meli itus; BMI = body mass index; AVR = aortic valve replacement