Table 1.

Effect of Provinol (PV) (40 mg/kg diluted in tap water) on body weight, urine output, systolic blood pressure (SBP), and creatinine clearance in cyclosporine A (CsA)-treated rats (15 mg/kg/day SC)

Treatment	Body weight (g)	Urine output 24 hr (ml)	SBP (mmHg)	Creatinine clearance (ml/min/kg)
Control (olive oil)	290 ±9.2	8.9 ± 0.73	115 ± 5.1	2.9 ± 0.16
PV alone	295 ± 10.1	8.4 ± 0.41	112 ± 3.8	3.0 ± 0.22
CsA	190 ± 6.3∗	9.3 ± 0.51	225 ± 3.2∗	1.3 ± 0.09∗
CsA + PV	300 ± 7.9+	10.4 ± 0.89	130 ± 5.1+	3.2 ± 0.35+
Values are means ± SEM.

^∗ p≤0.05 vs control; ⁺ p≤0.05 CsA + PV vs CsA-treated animals.