Figure 7.

Immunocytochemical localization of circulating endogenous albumin across the glomerular wall of the wild-type (A), heterozygous (C), and homozygous (E) transgenic mice. Gold particles are located in the capillary lumen (L) and across the GBM. (B,D,F) Distribution of labeling across GBM. The histograms demonstrate changes in these distributions. In the wild-type animals (B) Labeling is rather concentrated on the subendothelial side of the GBM. For the transgenic mice, heterozygous (D) as well as homozygous (F), the labelings display rather homogeneous distributions.