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Cycloheximide is toxic to E. histolytica cells overexpressing SREHP and EhCoactosin. Transgenic trophozoites were exposed to 100 nM cycloheximide for 48 h, and viability was assessed. The data are presented as a percentage of untreated control cells and represent the means ± SD from 3 trials. Cycloheximide was toxic to both wild-type (WT) and transgenic amoebae. Therefore, cells overexpressing SREHP and EhCoactosin may not have a multidrug resistance phenotype.
