TABLE 3.

Common gene from Venn diagram analysis of HT-29 cells cochallenged with PC only versus poly(I·C) only, PC only versus poly(I·C) plus PC, and PC only versus poly(I·C) only versus poly(I·C) plus PC^a

Challenges compared, common immune gene protein	Function	Immune pathway	Fold changeb
			PC	Poly(I·C)	Poly (I·C) + PC
PC only vs poly(I·C) only
JUN	Early response gene interacting with MYC to regulate AP1 genes	B cell receptor signaling pathway	2.50 ↓	3.60 ↑
DUSP1	Dual-specificity phosphatase 1 that reverses the activation of MAPK	MAPK signaling pathway	2.27 ↓	2.87 ↑
PC only vs poly(I·C) + PC, FOS	Nuclear phosphoprotein that forms a complex with the JUN/AP-1 complex	MAPK signaling pathway Toll-like receptor signaling	2.00 ↓		2.08 ↓
PC only vs poly(I·C) only vs poly(I·C) + PC, EGR1	Activator of the transcription of target genes required for mitogenesis and differentiation	MAPK signaling pathway	2.08 ↓	2.10 ↑	2.22 ↓

^aImmune gene function data are from GeneCards (http://www.genecards.org), and immune pathway data are from KEGG (http://www.genome.jp/kegg/pathway.html).

^bFold change or expression ratio = 2^log₂ratio. ↑, upregulation; ↓, downregulation. A 2-fold change in differentially expressed genes and a P value of <0.05 were considered statistically significant.