TABLE 3.

Humoral and cellular immunity against common pathogens^a

Pathogen	Cellular antigen	Group	No. of individuals with positive responses/total no. of individuals for:		P for IgG vs CMI	CMI
						P for:			No. of individuals with responsive cells/total no. of individuals for:		P for CD4+ vs CD8+
			IgG	CMI		CO vs HE-SPR	CO vs HE-SUM	HE-SPR vs HE-SUM	CD4+ cells	CD8+ cells
AdV-5	AdV-5 penton	CO	9/10	9/11		NSb	NS	NS	6/11	6/10	NS
		HE-SPR	11/11	11/11					7/11	9/11	NS
		HE-SUM	11/11	10/10					9/10	6/10	NS
CMV	CMV pp65	CO	4/11	10/11	0.024	NS	NS	NS	8/10	6/10	NS
		HE-SPR	9/11	11/11	NS				10/11	9/11	NS
		HE-SUM	9/11	10/10	NS				9/10	9/10	NS
Tetanus	TT	CO	10/11	6/11	NS	0.036	0.036	NS	6/11	3/11	NS
		HE-SPR	11/11	11/11	NS				8/11	5/11	NS
		HE-SUM	11/11	10/10	NS				10/10	5/10	0.033
VZV	VZV gE	CO	11/11	8/11	NS	NS	NS	NS	6/11	3/10	NS
		HE-SPR	11/11	9/11	NS				9/11	3/11	0.016
		HE-SUM	11/11	9/10	NS				9/10	4/10	0.058
VZV	VZV IE62	CO	11/11	11/11	NS	NS	NS	NS	10/11	7/11	NS
		HE-SPR	11/11	11/11	NS				9/11	9/11	NS
		HE-SUM	11/11	10/10	NS				10/10	9/10	NS
VZV	VZV IE63	CO	11/11	6/11	0.036	0.036	NS	NS	5/11	5/11	NS
		HE-SPR	11/11	11/11	NS				8/11	9/11	NS
		HE-SUM	11/11	9/10	NS				8/10	6/10	NS

^aShown is memory against pathogens using either humoral (IgG) or cell-mediated immunity (CMI) (IFN-γ- or/and IL-2-producing T cells) as proxy. Fisher's exact test was used to compare immunity as assessed by IgG or CMI (against an antigen) for three sampling groups (P values of <0.10 are shown). CMI is compared among the three groups (P values of <0.10 are shown). For each antigen, the presence of CD4⁺ and CD8⁺ IFN-γ or/and IL-2 responses are assessed and compared with each other per antigen and per group (P values of <0.10 are shown).

^bNS, nonsignificant.