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. 2014 Mar 18;8:92. doi: 10.3389/fnbeh.2014.00092

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Copyright © 2014 Gangarossa, Laffray, Bourinet and Valjent.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of the T-type calcium channel inhibitor TTA-A2 on psychostimulants-induced locomotor activity. (A) Histograms show the effect of TTA-A2 (1 mg/kg, p.o.) on d-amphetamine-sensitized mice. Data (means ± SEM) were analyzed using two-way ANOVA: A (Treatment × Genotype: F_{(1, 28)} = 26.47, P < 0.0001; Treatment: F_{(1, 28)} = 2.595, P = 0.1185; Genotype: F_{(1, 28)} = 53.99, P < 0.0001). Specific comparisons: *** p < 0.001 (WT-TTA-A2+d-amph vs. WT-Veh+d-amph) and °°° p < 0.001 (KO-Veh+d-amph vs. WT-Veh+d-amph). (B and C) Curves showing the behavioral profile of T-type channels blocker TTA-A2 in WT (B, n = 9) and Ca_v3.2 KO (C, n = 7) d-amphetamine-treated mice. Data (means ± SEM) were analyzed using two-way ANOVA: B (Treatment × Time: F_{(14, 224)} = 9.302, P < 0.0001; Time: F_{(14, 224)} = 34.60, P < 0.0001; Treatment: F_{(1, 16)} = 83.58, P < 0.0001); C (Treatment × Time: F_{(14, 168)} = 2.717, P < 0.01; Time: F_{(14, 168)} = 85.72, P < 0.0001; Treatment: F_{(1, 12)} = 2.108, P = 0.1722). (D) Histograms show the effect of TTA-A2 (1 mg/kg, p.o.) on cocaine-sensitized mice. Data (means ± SEM) were analyzed using two-way ANOVA: A (Treatment × Genotype: F_{(1, 28)} = 24.15, P < 0.0001; Treatment: F_{(1, 28)} = 27.96, P < 0.0001; Genotype: F_{(1, 28)} = 34.54, P < 0.0001). Specific comparisons: *** p < 0.001 (WT-TTA-A2+Coc vs. WT-Veh+Coc) and °°° p < 0.001 (KO-Veh+Coc vs. WT-Veh+Coc). (E and F) Curves showing the behavioral profile of T-type calcium channels blocker TTA-A2 in WT (E, n = 9) and Ca_v3.2 KO (F, n = 7) cocaine-treated mice. Data (means ± SEM) were analyzed using two-way ANOVA: E (Treatment × Time: F_{(14, 224)} = 2.31, P < 0.01; Time: F_{(14, 224)} = 37.34, P < 0.0001; Treatment: F_{(1, 16)} = 50.35, P < 0.0001); F (Treatment × Time: F_{(14, 168)} = 1.768, P < 0.05; Time: F_{(14, 168)} = 29.27, P < 0.0001; Treatment: F_{(1, 12)} = 0.8157, P = 0.3842).