TABLE 1.
Evaluation of module 1 (isoniazid and rifampin) of the AID TB Resistance line probe assay using clinical M. tuberculosis strains (n = 70, Switzerland)
| Isoniazida |
Rifampin, RpoB |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
inhA |
KatG |
||||||||||||
| No. of isolates | AID module 1 |
DNA sequencing | AID module 1 |
DNA sequencing | AID module 1 |
DNA sequencing | |||||||
| wt (−16, −15, −8) | Mutant (−16, −15, −8) | wt 315 | mut315 | wt 513–516 | mut516 | wt 522–526 | mut526 | wt 529–533 | mut531 | ||||
| 1 | − | + | C-15T | − | + | S315T | + | − | − | + | + | − | H526D |
| 1 | − | + | C-15T | − | + | S315T | + | − | + | − | − | + | S531L |
| 1 | − | + | C-15T | + | − | wt | − | + | + | − | − | + | D516Y/S531L |
| 3 | − | + | C-15T | + | − | wt | + | − | + | − | − | + | S531L |
| 5 | − | + | C-15T | + | − | wt | + | − | + | − | + | − | wt |
| 1 | − | + | T-8C | − | + | S315T | + | − | − | + | + | − | H526Y |
| 10 | + | − | wt | − | + | S315T | + | − | + | − | + | − | wt |
| 1 | + | − | wt | − | + | S315T | − | + | + | − | + | − | D516Y |
| 1 | + | − | wt | − | + | S315T | − | + | − | + | + | − | D516Y/H526D |
| 6 | + | − | wt | − | + | S315T | + | − | − | + | + | − | H526D |
| 18 | + | − | wt | − | + | S315T | + | − | + | − | − | + | S531L |
| 1 | + | − | wt | + | − | wt | − | + | + | − | + | − | D516V |
| 2 | + | − | wt | + | − | wt | + | − | − | + | + | − | H526Y |
| 6 | + | − | wt | + | − | wt | + | − | + | − | − | + | S531L |
| 13 | + | − | wt | + | − | wt | + | − | + | − | + | − | wt |
a
−, no signal (band); +, signal (band); wt, wild type.