. 2014 Mar;52(3):781–789. doi: 10.1128/JCM.02701-13

TABLE 1.

Genes associated with drug resistance phenotypes in XDR-TB strains and PCR primers used for Sanger sequencing^a

Drug resistance phenotype(s)^b	Primary gene and/or promoter associated with resistance in the literature^c	PCR primer used to amplify gene/fragment for sequencing (5′ to 3′)	Gene/fragment size, including primers (bp)
INH^r	katG	CATGAACGACGTCGAAACAG	270
INH^r	katG	CTCTTCGTCAGCTCCCACTC	270
INH^r	inhA promoter	AGAAAGGGATCCGTCATGGT	340
INH^r	inhA promoter	GTCACATTCGACGCCAAAC	340
RIF^r	rpoB	CGTGGAGGCGATCACACCGCAGTT	215
RIF^r	rpoB	AGTGCGACGGGTGCACGTCGCGGACCT	215
MOX^r/OFX^r	gyrA	GGTGCTCTATGAAATGTTCG	234
MOX^r/OFX^r	gyrA	GCTTCGGTGTACCTCATCG	234
MOX^r/OFX^r	gyrB	CGATGTTCCAGGCGATACTT	163
MOX^r/OFX^r	gyrB	ATCTTGTGGTAGCGCAGCTT	163
AMK^r KAN^r CAP^r	rrs	GTAATCGCAGATCAGCAACG	216
AMK^r KAN^r CAP^r	rrs	TTTTCGTGGTGCTCCTTAGAA	216
AMK^r KAN^r CAP^r	eis promoter/eis	AAATTCGTCGCTGATTCTCG	387
AMK^r KAN^r CAP^r	eis promoter/eis	CGCGACGAAACTGAGACC	387
AMK^r KAN^r CAP^r	tlyA	GTCTCTGGCCGAACTCGAAG	1,000
AMK^r KAN^r CAP^r	tlyA	ATTGTCGCCCAATACTTTTTCTAC	1,000

XDR-TB, extensively drug-resistant tuberculosis.

INH, isoniazid; RIF, rifampin; MOX, moxifloxacin; OFX, ofloxacin; AMK, amikacin; KAN, kanamycin; CAP, capreomycin.

Data sources are references 14, 15, and 16.