TABLE 3.

Significantly differently expressed genes between the wild type and the ccg-8 mutant in response to ketoconazole stress^a

Category and locusb	Gene	Function	TPM in WT	TPM in WT(k)	Fold change [WT(k)/WT]	P value	TPM in Δccg-8	TPM in Δccg-8(k)	Fold change [Δccg-8(k)/Δccg-8]	P value	Fold change [Δccg-8(k)/WT(k)]	Sensitivity to ketoconazole compared to WT's
Upregulated genes
NCU09691	kts-3	Hypothetical protein	0.01	14.83	1483	8.88E−16	0.01	3.87	387	0.00012	0.26	Hypersensitive
NCU02084		Arginase	13.82	1007.43	72.90	9.08E−14	67.92	304.5	4.48	2.78E−13	0.30	Hypersensitive
NCU09635	kts-4	Hypothetical protein	3.17	216.04	68.15	7.57E−07	8.3	69.88	8.42	2.00E−11	0.32	Hypersensitive
NCU01315	gt41-1	UDP-N-acetylglucosaminyltransferase	2.59	38.9	15.02	2.57E−06	20.46	11.3	0.55	0.002807	0.29	Hypersensitive
NCU08957	kts-5	Hypothetical protein	5.47	69.4	12.69	4.61E−09	16.31	27.06	1.66	0.002712	0.39	Hypersensitive
NCU01633	hxt13	Hexose transporter HXT13	377.04	4679.24	12.41	1.73E−12	622.5	1352.73	2.17	0	0.29	Hypersensitive
NCU00247	kts-6	Hypothetical protein	6.62	64.36	9.72	3.39E−10	7.71	13.98	1.81	0.013643	0.22	Hypersensitive
NCU01302		Hydrolase	8.63	41.98	4.86	3.78E−12	17.2	9.81	0.57	0.009111	0.23	Hypersensitive
NCU00611	kts-7	Hypothetical protein	8.06	30.78	3.82	1.54E−11	6.52	14.57	2.23	0.001244	0.47	Hypersensitive
NCU00248	kts-8	Hypothetical protein	59	216.04	3.66	3.92E−13	92.24	85.05	0.92	0.322136	0.39	Hypersensitive
Downregulated genes
NCU04334	cpn10	Chaperonin	45.76	14.55	0.32	1.18E−14	18.09	31.22	1.73	0.000581	2.15	Resistant
NCU04923	gcy-1	Glycerol dehydrogenase	83.76	33.86	0.40	1.77E−18	462.4	163.85	0.35	1.7E−110	4.84	Resistant

^aWT, wild type; WT(k) or Δccg-8(k), wild type or Δccg-8 mutant treated with ketoconazole, respectively; TPM, number of locus tags per million; NA, the mutant was not available.

^bLocus numbers and function were annotated according to the N. crassa genome assembly (http://www.broadinstitute.org/annotation/genome/neurospora/).