TABLE 3.
Antifungal activities of fluconazole, itraconazole, voriconazole, and posaconazole against the 781 isolates collecteda
| Species (nb) | Statistic | Antifungal activity (mg/liter) |
||||||
|---|---|---|---|---|---|---|---|---|
| Fluconazole |
Itraconazole, EUCAST | Voriconazole |
Posaconazole |
|||||
| EUCAST | CLSI | EUCAST | CLSI | EUCAST | CLSI | |||
| C. albicans (348) | GM | 0.21 | 0.39 | 0.016 | 0.016 | 0.009 | 0.015 | 0.006 |
| Mode | 0.25 | 0.25 | 0.015 | 0.015 | 0.007 | 0.015 | 0.007 | |
| MIC90 | 0·25 | 1 | 0·015 | 0.015 | 0.03 | 0·015 | 0.015 | |
| Range | ≤0.12–≥64 | 0.12–>64 | ≤0.015–≥8 | ≤0.015–≥8 | 0.0017–>2 | ≤0.015–8 | 0.0017–>2 | |
| C. parapsilosis (191) | GM | 0.48 | 0.64 | 0.018 | 0.017 | 0.008 | 0.016 | 0.008 |
| Mode | 0.5 | 0.5 | 0.015 | 0.015 | 0.007 | 0.015 | 0.007 | |
| MIC90 | 1 | 2 | 0.03 | 0.03 | 0.015 | 0.015 | 0.031 | |
| Range | ≤0.12–64 | 0.06–64 | ≤0.015–0.25 | ≤0.015–0.5 | 0.0017–0.25 | ≤0.015–0·12 | 0.0017–>2 | |
| C. glabrata (103) | GM | 3.074 | 10 | 0.127 | 0.12 | 0.11 | 0.124 | 0.25 |
| Mode | 2 | 8 | 0.06 | 0.12 | 0.12 | 0.12 | 0.25 | |
| MIC90 | 16 | 64 | 1 | 0.5 | 0.5 | 0.5 | 1 | |
| Range | 0.5–≥64 | 1–>64 | ≤0.015–≥8 | ≤0.015–8 | 0.003–>2 | ≤0.015–8 | 0.015–>2 | |
| C. tropicalis (59) | GM | 1.83 | 0.71 | 0.057 | 0.13 | 0.026 | 0.047 | 0.023 |
| Mode | 0.5 | 1 | 0.015 | 0.03 | 0.03 | 0.015 | 0.03 | |
| MIC90 | >64 | 1 | 8 | >8 | 0.06 | 8 | 0.06 | |
| Range | ≤0.12–≥64 | 0.12–8 | ≤0.015–≥8 | ≤0.015–≥8 | 0.003–0.25 | ≤0.015–≥8 | 0.0017–0.12 | |
| C. krusei (15) | GM | 33.5 | 38.5 | 0.066 | 0.3 | 0.15 | 0.048 | 0.1 |
| Mode | 32 | 32 | 0.12 | 0.5 | 0.12 | 0.06 | 0.12 | |
| MIC90 | 64 | 64 | 0.25 | 0.5 | 0.25 | 0.12 | 1 | |
| Range | 16–64 | 16–64 | ≤0.015–0.25 | ≤0.015–1 | 0.03–0.25 | ≤0.015–0.12 | 0.015–2 | |
| C. guilliermondii (13) | GM | 3.22 | 5.51 | 0.22 | 0.12 | 0.061 | 0.075 | 0.054 |
| Mode | 4 | 8 | 0.12 | 0.12 | 0.031 | 0.06 | 0.12 | |
| MIC90 | 16 | 32 | 1 | 0.25 | 0.5 | 0.25 | 0.25 | |
| Range | ≤0.12–32 | 0.5–64 | 0.06–2 | 0.06–0.25 | 0.007–0.5 | ≤0.015–0.25 | 0.003–0.25 | |
| C. lusitaniae (10) | GM | 0.45 | 1.19 | 0.02 | 0.023 | 0.01 | 0.018 | 0.009 |
| Mode | 0.25 | 0.5 | 0.015 | 0.015 | 0.007 | 0.015 | 0.003 | |
| MIC90 | 32 | 32 | 0.12 | 0.5 | 0.12 | 0.06 | 0.03 | |
| Range | ≤0.12–64 | 0.5–64 | ≤0.015–0.25 | ≤0.015–0.5 | 0.003–0.25 | ≤0.015–0.06 | 0.003–0.031 | |
| Other (781) | GM | 1.92 | 1 | 0.066 | 0.07 | 0.017 | 0.061 | 0.029 |
| Mode | 0.5 | 1 | 0.015 | 0.015 | 0.007 | 0.015 | 0.015 | |
| MIC90 | >64 | 64 | 2 | 4 | 1/2 | 2 | 0.5/0.5 | |
| Range | ≤0.12–≥64 | 0.06–>64 | ≤0.015–4 | ≤0.015–≥8 | 0.0017–>2 | ≤0.015–≥8 | 0.0017–>2 | |
a
“Other” includes the remaining Candida and non-Candida species. GM, geometric mean.
b
n, no. of isolates.