FIG 1.

RAW 264.6 macrophages were infected with B. pseudomallei at a multiplicity of infection (MOI) of 5 and treated overnight with either ceftazidime or select substituted diphenyl ethers. B. pseudomallei 1026b was treated with 10 μg/ml compounds for 18 h, macrophages were lysed, and lysate was plated on solid medium for bacterial enumeration (A). B. pseudomallei Bp400 was treated at the same concentration with ceftazidime and at 10, 1, and 0.1 mg/ml with substituted diphenyl ethers to observe concentration-dependent inhibition. Again macrophages were lysed, and lysate was plated onto solid medium for bacterial enumeration (B).