TABLE 1.
In vitro activities of FabI inhibitors against B. pseudomalleia
| FabI inhibitor | MIC (mg/liter) for strain |
Vero cell cytotoxicity, LD50 (mg/liter) | |
|---|---|---|---|
| B. pseudomallei 1026b | B. pseudomallei Bp400 | ||
| PT51 | 2 | 2 | 190.2 |
| PT52 | 1 | 0.125 | 89.8 |
| PT55 | 4 | 0.5 | 164.9 |
| PT68 | 4 | 0.5 | 152.9 |
| Doxycycline | 0.5 | 0.125 | NDb |
| Ceftazidime | 2 | 1 | ND |
a
MICs of FabI1 inhibitors against wild-type and efflux-compromised B. pseudomallei strains. MICs were determined using the broth microdilution method.
b
ND, not determined in this study.