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Atazanavir tissue-to-plasma concentration ratios in WT mice (squares and solid line) and TKO mice (triangles and dashed line). (A) Cbrain/Cplasma; (B) Ctestes/Cplasma. Results are shown as the mean ± SEM (n = 4 animals per time point per group). Statistically significant differences are indicated (*, P < 0.05).
