TABLE 3.
Probability of simulated subjects achieving unbound concentrations of ≥40% T > MIC following the first dose for each regimen and fraction of the dosage interval spent above the MIC for each regimen
| Regimen | Result for MIC (mg/liter) of: |
|||||
|---|---|---|---|---|---|---|
| 0.5 |
1 |
2 |
||||
| Probability of target attainment (≥40% T> MIC) | Fraction of dosing interval with unbound concn > MIC median (range) | Probability of target attainment (≥40% T > MIC) | Fraction of dosing interval with unbound concn > MIC median (range) | Probability of target attainment (≥40% T > MIC) | Fraction of dosing interval with unbound concn > MIC median (range) | |
| 500 mg q12h | 1.000 | 0.999 (0.999–0.999) | 1.000 | 0.999 (0.833–0.999) | 1.000 | 0.992 (0.50–0.999) |
| 500 mg q24h | 1.000 | 0.999 (0.583–0.999) | 0.999 | 0.916 (0.333–0.999) | 0.962 | 0.583 (0.167–1.000) |
| 750 mg q24h | 1.000 | 0.999 (0.667–0.999) | 1.000 | 0.999 (0.5–0.999) | 0.999 | 0.750 (0.333–1.000) |
| 1,000 mg q24h | 1.000 | 0.999 (0.75–0.999) | 1.000 | 0.999 (0.583–0.999) | 0.999 | 0.917 (0.330–1.000) |