TABLE 2.

Pharmacodynamic response against P. aeruginosa URMC1 and URMC2 for regimens simulating those for hepatic and renal failure patients

Dosage regimen	fAUC (mg · h/liter)		URMC1				URMC2
			Log10 AUCCFUa (CFU · h/ml)		Reduction in bacterial burden (%)b		Log10 AUCCFU (CFU · h/ml)		Reduction in bacterial burden (%)
	0–24 h	0–48 h	0–24 h	0–48 h	0–24 h	0–48 h	0–24 h	0–48 h	0–24 h	0–48 h
Hepatic
Traditional
0.6 mg/liter every 24 h × 2 doses	2.76	5.53	8.93	9.08	36.9	25.4	9.08	9.18	-8.07	12.0
1.0 mg/liter every 24 h × 2 doses	4.59	9.21	8.63	8.88	68.2	53.4	8.91	9.09	28.4	33.3
0.6 mg/liter every 12 h × 4 doses	5.32	10.9	8.89	8.97	42.5	41.6	9.11	9.17	-13.4	-3.24
1.0 mg/liter every 12 h × 4 doses	8.87	18.1	8.89	8.94	41.9	46.5	9.07	9.09	4.61	20.9
2.0 mg/liter every 24 h × 2 doses	9.18	18.4	8.36	8.76	82.7	64.7	8.50	8.66	72.2	68.1
2.0 mg/liter every 12 h × 4 doses	17.7	36.2	8.41	8.43	81.0	83.4	8.74	8.75	55.8	63.5
High dose
4.0 mg/liter every 24 h × 2 doses	18.4	36.8	8.26	8.32	86.4	87.1	8.82	8.91	40.3	40.1
4.0 mg/liter every 12 h × 4 doses	35.5	72.4	8.32	8.92	84.4	49.0	8.88	8.94	36.6	40.9
8.0 mg/liter every 24 h × 2 doses	36.7	73.7	7.68	7.72	96.4	96.7	8.65	8.81	59.9	53.1
8.0 mg/liter every 12 h × 4 doses	70.9	144	7.65	7.71	94.5	95.2	8.75	8.85	54.9	53.7
Front loaded
6 mg/liter every 24 h × 1 dose followed by 2 mg/liter every 24 h × 1 dose	27.6	36.9	8.05	8.22	91.6	89.7	8.72	8.89	52.6	43.0
6 mg/liter × 1 dose followed by 2mg/liter × 3 doses	36.1	54.7	8.04	9.07	91.8	28.0	8.77	8.90	47.8	45.7
10 mg/liter every 24 h × 1 dose followed by 2mg/liter every 24 h × 1 dose	45.9	55.4	7.83	8.27	94.9	88.5	8.56	8.75	67.3	58.6
10 mg/liter every 12 h × 1 dose followed by 2mg/liter every 12 h × 3 doses	54.5	73.1	7.27	8.53	98.6	77.1	8.60	8.77	68.2	60.5
Renal
Traditional
0.6 mg/liter every 24 h × 2 doses	8.65	20.1	9.13	9.28	61.0	60.4	9.17	9.26	62.2	65.3
1.0 mg/liter every 24 h × 2 doses	14.4	33.5	9.06	9.11	66.9	73.2	9.17	9.18	62.2	70.8
2.0 mg/liter every 24 h × 2 doses	28.8	67.0	9.04	9.05	68.1	76.7	9.13	9.13	65.4	74.2
High dose
4.0 mg/liter every 24 h × 2 doses	57.7	134	8.10	8.10	96.3	97.4	8.47	8.49	92.3	94.2
8.0 mg/liter every 24 h × 2 doses	115	268	8.06	8.06	96.7	97.6	8.24	8.27	95.6	96.5
Front loaded
6 mg/liter every 24 h × 1 dose followed by 2 mg/liter every 24 h × 1 dose	86.5	143	8.07	8.07	96.6	97.6	8.06	8.10	97.0	97.6

^aLog₁₀ AUCCFU, log of the area under the CFU/ml-versus-time curve.

^bReduction in bacterial burden was computed as per equation 1.