FIG 6.
Growth curves of HRVc15 (A), HRV16 (B), and HRVc11 (C) in the HAE cultures. HAE cells in a 24-well format were infected with HRVc15 or HRV16 produced in H1-HeLa cells at 3.8 × 107 copies of RNA/well in the presence of 0.5% DMSO or 1 μM rupintrivir, incubated for 3 h, and washed to remove the virus inoculum. Cultures were subsequently incubated at 33°C. Virus production into the HAE apical compartment was determined by RT-qPCR. Error bars represent the standard deviations of the means from triplicate tests.