TABLE 2.
Antiviral activity of HRV inhibitors in HAE culturesa
| Antiviral | EC50 (nM) |
|||
|---|---|---|---|---|
| HRVc15 (HAE culture) | HRVc11 (HAE culture) | HRV16 |
||
| HAE culture | HeLa culture | |||
| Rupintrivir | 58 ± 39 | 56 ± 27 | 22 ± 16 | 57 ± 18 |
| MK-0608 | 2,416 ± 556 | 4,176 ± 519 | 1,847 ± 479 | 12,020 ± 3,953 |
| PIK93 | 225 ± 103 | 342 ± 81 | 127 ± 50 | 574 ± 115 |
| Pleconaril | >10,000 | >10,000 | 899 ± 465 | 722 ± 291 |
| Win 56291 | 4,762 ± 3,296 | 5,107 ± 1,538 | 54 ± 18 | 160 ± 52 |
| Pirodavir | >20,000 | >10,000 | 402 ± 103 | ND |
a
Values are means and standard deviations from multiple (n ≥ 3) experiments, with the exception of those for Win 56291 and pirodavir, which were tested in 2 experiments.