TABLE 1.

Activities of solithromycin and comparator antimicrobial agents against Streptococcus agalactiae

Organism	Antimicrobial drug	MIC (mg/liter)
		50%	90%	Range observed	Range tested
Erythromycin-resistant GBS (n = 62)	Solithromycin	0.03	0.125	≤0.008–1	0.008–4
	Penicillin	0.032	0.047	0.012–0.06	0.002–32
	Erythromycina	>8	>8	0.5->8	0.25–8
	Erythromycinb	>256	>256	0.5->256	0.016–256
	Azithromycin	>256	>256	0.19->256	0.016–256
	Clarithromycin	>256	>256	0.25->256	0.016–256
Erythromycin-susceptible GBS (n = 10)	Solithromycin	≤0.008	0.015	≤0.008–0.03	0.008–4
	Penicillin	0.032	0.047	0.012–0.047	0.002–32
	Erythromycina	≤0.25	≤0.25	≤0.25	0.25–8
	Erythromycinb	0.047	0.047	0.012–0.064	0.016–256
	Azithromycin	≤0.125	≤0.125	0.019–0.19	0.016–256
	Clarithromycin	0.047	0.047	0.023–0.047	0.016–256

^aBroth microdilution test.

^bEtest.