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. 2014 Mar;58(3):1693–1698. doi: 10.1128/AAC.02210-13

TABLE 2.

MIC50s and MIC90s of solithromycin and comparator drugs against S. agalactiae strains with defined macrolide-resistant genotypes

Drug MIC (mg/liter) for strains with different macrolide resistance mechanisms (no. of strains)
erm(B) (26)
mef(A/E) (22)
MIC50 MIC90 MIC50 MIC90
Solithromycin 0.03 0.06 0.03 0.125
Penicillin 0.032 0.047 0.047 0.047
Erythromycina >8 >8 >8 >8
Erythromycinb >256 >256 6 >256
Azithromycin >256 >256 12 >256
Clarithromycin >256 >256 6 >256
a

Broth microdilution test.

b

Etest.