TABLE 4.
Results from CART and univariate logistic regression analyses to determine which pharmacodynamic indices significantly predict microbiological response and the associated breakpoints for success
| Parameter | Classification and regression |
Logistic regression |
|||
|---|---|---|---|---|---|
| % breakpoint | % response rate (above, below) | P | Odds ratio (95% confidence interval) | P | |
| % ƒT > MIC | 53 | 63.6, 14.3 | 0.017 | 10.50 (1.19–92.48) | 0.034 |
| ƒAUC/MIC | 529 | 92.3, 40.4 | <0.001 | 17.68 (3.73–83.79) | <0.001 |
| ƒCmax/MIC | 6 | 67.7, 9.1 | <0.001 | 21.00 (2.51–175.56) | 0.005 |
| ƒCmin/MIC | 12 | 92.0, 41.7 | <0.001 | 16.10 (3.40–76.21) | <0.001 |