FIG 2.

(A) Schematic depiction of ARM58 deletion constructs used for panels B and C. The shaded boxes represent the four DUF1935 putative domains. The black box signifies the putative transmembrane domain (TMD). The numbers indicate the positions relative to the wild-type amino acid sequence; insertion, 31-amino-acid sequence absent from ARM58rel. (B) Sb^III IC₅₀s (μM) for L. infantum carrying the indicated ARM58 variants. *, P < 0.05 (n = 4) relative to full-length ARM58. (C) As for panel B, but with further shortened ARM58 variants (n = 4).