TABLE 2.
Results of the prodrug screena
| Chemical library (no. of compounds) | No. of prodrug hits for E. coli | Hit rate (%) |
|---|---|---|
| ChemBridge library (11,280) | 4 | 0.05 |
| ChemDiv, MPEX library (23,040) | 41 | 0.18 |
| Enamine library (20,160) | 5 | 0.025 |
a
Compounds were tested against E. coli at 35 μg/ml in wells of a microtiter plate with Mueller-Hinton broth containing alamarBlue. Fluorescence changes were detected after incubation for 4 h. The overall E. coli hit rate was 0.09%. The total number of compounds screened was 54,480. The total number of hits was 50.